Manchester City boss Sven-Goran Eriksson has failed to bring in a new keeper so 20-year-old rookie Kasper Schmeichel continues in goal.
Brazilian midfielder Elano is expected to shake off a knock so Eriksson is likely to name an unchanged line-up.
Manchester United winger Cristiano Ronaldo starts a three-match ban for his sending-off against Portsmouth.
He joins the injured Wayne Rooney, Owen Hargreaves, Louis Saha, Anderson and Gary Neville on the sidelines.
The 148th competitive Manchester derby, 137th in the league and 21st in the Premier League is the most eagerly anticipated in years.
It throws up a tactical battle between the most recently appointed Premier League manager in the Sven-Goran Eriksson and the longest serving in Sir Alex Ferguson.
City have made their best start ever to a Premier League season, and United their worst since 1998. Indeed the Red Devils have not won a league game since the last Manchester derby at Eastlands on 5 May.
In beating West Ham (a) and Derby (h), City have a tremendous platform to improve of their previous best of seven points from the first three games of a Premier League campaign.
Despite being held at home by Reading and away to Portsmouth, and being four points behind Chelsea, there is no panic at Old Trafford. In 1998, they famously went on from a poor start to clinch the Premiership, FA Cup and Champions League treble.
City are superior to United by four points and 10 places in the embryonic Premier League table. They last went into a derby clash higher in the table than their deadly rivals on 10 September 2005 at Old Trafford when they were second and United fourth, and the spoils were shared in a 1-1 draw. More significantly, it's 29 years since City could afford to lose a derby and still stay above United. The last time was a 2-2 draw at Old Trafford in March 1978.
City scored their first home goal since New Years Day on Wednesday, while Paul Scholes' historic strike at Portsmouth was United's first from open play in five Premier League matches since 28 April.
Rolando BIANCHI, GEOVANNI and Michael JOHNSON have each scored one of City's three goals to date.
Paul SCHOLES has netted United's only Premier League goal so far. His strike at Portsmouth gave him the record outright as Manchester United's highest scorer of Premier League goals. He has netted 96, beating Ruud van Nistelrooy's total of 95. Ryan GIGGS has scored 93 times in the Premier League.
GIGGS is a double short of 100 career League goals.
If on the field from the outset:-
Gary NEVILLE will be making his 350th Premier League start - all for the Red Devils.
John O'SHEA will be making his 200th start for Manchester United.
RONALDO (three matches)
The winner of the Manchester league derby at City has alternated in the last four years. The Citizens must win this time if that pattern is to continue.
United have won four times as many Manchester Premier League derbies as City.
The Red Devils completed the double over their rivals last season.
Sir Alex Ferguson's record in his 30 Manchester derbies is won 16, drawn nine and lost five.
Home and away
League (inc PL): Man City 35 wins, Man Utd 53, Draws 48
Prem: Man City 3 wins, Man Utd 12, Draws 5
at Man City only
League (inc PL): Man City 21 wins, Man Utd 24, Draws 23
Prem: Man City 3 wins, Man Utd 6, Draws 1
I Believe Man United gonna win this match. United now is under pressure after played 2 draw. When United are asked a question, they nearly always come up with an answer. You get a reaction with United and I think that's what we'll get on Sunday.
City have made a very good start with 2 win but with many new player, i think they still need time to settling in so they maybe have a inconsistent game early season.
Manchester City vs Manchester Utd 1.95 1/2 : 0 1.95
Pick : Manchester United